Krishanu Saha is an Assistant Professor in the Department of Biomedical Engineering at the University of Wisconsin-Madison. He is also a member of the Wisconsin Institute for Discovery (WID). Prior to his arrival in Madison, Dr. Saha studied Chemical Engineering at Cornell University and at the University of California in Berkeley. In 2007 he became a Society in Science: Branco-Weiss fellow in the laboratory of Professor Rudolf Jaenisch at the Whitehead Institute for Biomedical Research at MIT and in the Science and Technology Studies program at Harvard University with Professor Sheila Jasanoff in Cambridge, Massachusetts. At UW-Madison, his lab is now funded by the NIH, NSF and EPA to perform research on pluripotent stem cells, regenerative medicine, disease modeling and synthetic biology. His lab has developed a wide array of engineering approaches that seek to generate new cells, organoids and tissues from patient samples, as well as a suite of gene-editing technologies to knockout, correct or insert transgenes into human cells. He is a Member of the Forum on Regenerative Medicine organized by the National Academies of Sciences, Engineering and Medicine and the Leadership Team of the NSF Center for Cell Manufacturing Technologies (CMaT).
The Saha lab is focused on human cell engineering. Our research generates new technologies and tools for genome engineering and epigenetic reprogramming, with an ultimate aim of building in synthetic functionality into human cells and bodies. Current projects involve cell reprogramming, somatic gene editing, ex vivo gene editing and engineered T cell therapy.