2017 Regenerative Medicine Workshop @ Hilton Head
Synergizing Science, Engineering, and Clinical Translation


Harbour Town Clubhouse
11 Lighthouse Lane
Hilton Head Island, SC 29928


PROGRAM

Day 1 – Wednesday, March 1, 2017

SESSION I
Session Chair - Bob Guldberg, Ph.D. - Georgia Tech

4:00 p.m. – Welcome and Opening Remarks – Robert E. Guldberg, Ph.D. – Georgia Tech 

4:05 p.m. – Keynote – Jennifer West, Ph.D. – Duke University
Biomimetic Patterning to Control Cell Behaviors

4:35 p.m. – Greg Hudalla, Ph.D. – University of Florida
Bottom-up Hydrogels with Multi-scale Hierarchical Order via Synthetic Glycopeptide Self-assembly

4:55 p.m. – William Murphy, Ph.D. – University of Wisconsin-Madison
Assembly of Stem Cell-derived Human Tissues for Screening Applications

5:15 p.m. – Nerem Lecture Introduction

5:20 p.m. – Nerem Lecturer – Jeffrey Hubbell, Ph.D. – University of Chicago 
Biomolecular Engineering in Regenerative Medicine and Immunotherapies

6:30 p.m. – Mayo Clinic Welcome Reception until 8:00 p.m. - The Inn & Club at Harbour Town lobby, 7 Lighthouse Lane 

8:00 p.m. – Trainee Networking Event and Social – Networking Tips Every Trainee Needs to Know - Kacey Marra, Ph.D. - University of Pittsburgh - Harbour Town Clubhouse


Day 2 – Thursday, March 2, 2017 

7:45 a.m. – Continental breakfast

SESSION II
Session Chair - Krishanu Saha, Ph.D. - University of Wisconsin-Madison

8:20 a.m. – Keynote – Ronald Germain, M.D., Ph.D. – National Institute of Allergy and Infectious Disease/National Institutes of Health 
Imaging the Immune System: Insights and Lessons for Regenerative Medicine

8:50 a.m. – Susan Thomas, Ph.D. – Georgia Tech
Multi-stage Drug Delivery System for Enhanced Payload Delivery to Lymph Node Cells

9:10 a.m. – Ed Botchwey, Ph.D. – Georgia Tech
Developing Immunologically Smarter Materials and Therapies

9:30 a.m. – James Dahlman, Ph.D. – Georgia Tech / Emory University
DNA Barcoded Nanotechnology for High Throughput in vivo Nanoparticle Discovery

SESSION III
Session Chair - Edmund Waller, M.D., Ph.D. - Emory University

Rapid Fire Session I

9:50 a.m. – Ramak Khosravi – Yale University
Computational Model-driven Design of Tissue-engineered Vascular Grafts

9:55 a.m. – Joseph Bartolacci – University of Pittsburgh
Matrix-bound Vesicles can Recapitulate ECM Effects on Macrophage Phenotype

10:00 a.m. – Daniel Hachim – University of Pittsburgh
Unveiling Macrophage Populations and Mechanisms Driving the Better Remodeling Outcomes Associated with Shifting Phenotype in the Host Response Against Biomaterials

10:05 a.m. – Cheryl San Emeterio – Georgia Tech
Age-dependent Immune Dysregulation during Repair of Volumetric Muscle Injury

10:10 a.m. – Nate Dwarshuis – Georgia Tech / Emory University
Functionalized Microcarriers for Enhanced CAR-T Cell Manufacturing

10:15 a.m. – Rapid Fire Discussion

10:25 a.m. – Break 

Rapid Fire Session II

10:45 a.m. – Melissa Alvarado-Velez – Georgia Tech
Immuno-suppressive Hydrogels for Stem Cell Delivery after Traumatic Brain Injury

10:50 a.m. – Mojibade Hassan – Emory University
Engineering the Optimal Stem Cell Graft: Why Bone Marrow is Better than G-CSF Mobilized Cells

10:55 a.m. – Eric Shin, M.D. – Emory University
Mesenchymal Stem Cells Require CD73 to Reduce Cardiac Inflammation and Improve Hemodynamic Function Following Myocardial Ischemia-reperfusion Injury

11:00 a.m. – Joseph Candiello, Ph.D. – University of Pittsburgh
Engineering Islet-specific Microvascular Network within Pancreatic Islet Organoids Derived from Human Pluripotent Stem Cells

11:05 a.m. – Gabriella DiBernardo – University of Pittsburgh
Long Gap Median Nerve Regeneration using Tissue Engineered Guides in a Non-human Primate Model

11:10 a.m. – Rapid Fire Discussion

SESSION IV
Session Chair - Kacey Marra, Ph.D. - University of Pittsburgh

11:20 a.m. – Keynote – Michael Levin, Ph.D. – Tufts University
Rewriting Pattern Memories: Harnessing Bioelectric Signaling for Transformative Applications in Regenerative Medicine

11:50 p.m. – Rolando Gittens, Ph.D. – Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP)
Cerebral Decellularized Extracellular Matrix as in vitro Model for Neural Development

12:10 p.m. – Ying Mei, Ph.D. – Clemson University
Toward Translation: Silicon Nanowires Synergize with Electrical Stimulation to Promote Ventricular Maturation of hiPSC-derived Cardiomyocytes

12:30 p.m. – Kelvin Brockbank, Ph.D. – Medical University of South Carolina
MALDI Imaging Mass Spectrometry for Evaluation of Changes in Heart Valves

12:50 p.m. – AFTERNOON OFF

5:00 p.m. – 8:00 p.m. – Poster Session and Reception (Poster judging 5–5:30pm) - Harbour Town Clubhouse & Conference Center


Day 3 – Friday, March 3, 2017

8:00 a.m. – Continental breakfast

SESSION V
Session Chair - Sean Palecek, Ph.D. - University of Wisconsin-Madison

8:30 a.m. – Keynote – Charles Gersbach, Ph.D. – Duke University
Genome and Epigenome Editing for Gene Therapy and Cell Programming

9:00 a.m. – Krishanu Saha, Ph.D. – University of Wisconsin-Madison
Precise Gene Editing of Human Cells using the CRISPR-Cas9 System

9:20 a.m. – Raymond Hickey, Ph.D. – Mayo Clinic
Ex vivo Gene and Cell Therapy in a Large Animal Model of Metabolic Liver Disease

9:40 a.m. – Aaron Levine, Ph.D. – Georgia Tech
Regenerative Medicine in a Time of Policy Uncertainty

10:00 a.m. – Break

SESSION VI
Session Chair - Kah Whye Peng, Ph.D. - Mayo Clinic

10:20 a.m. – Keynote – Amy Wagers, Ph.D. – Harvard Medical School
Towards Cell- and Gene-based Therapies for Muscle Degenerative Disease

10:50 a.m. – Young Jang, Ph.D. – Georgia Tech 
Redox Regulation of Muscle Stem Cell and Its Microenvironment

11:10 a.m. – Johnna Temenoff, Ph.D. – Georgia Tech / Emory University
Strategies to Reverse Tissue Degeneration in Rotator Cuff Injuries

11:30 a.m. - Chunfeng Zhao, M.D. – Mayo Clinic 
Engineered Allograft for Flexor Tendon Reconstruction and Regeneration

11:50 a.m. – WiCell Sponsor Lunch - Fairway Parlor - Harbour Town Clubhouse    

SESSION VII
Session Chair - Raymond Hickey, Ph.D. - Mayo Clinic

1:30 p.m. – Keynote – Molly Stevens, Ph.D. – Imperial College London
Exploring and Engineering the Cell Material Interface for Regenerative Medicine

2:00 p.m. – Valeria Milam, Ph.D. – Georgia Tech 
Selection of DNA Aptamers for Phosphatase Proteins

2:20 p.m. – Rebecca Levit, Ph.D. – Emory University
Minimally Invasive Delivery of Amiodarone Releasing Hydrogel to the Cardiac Epicardium

2:40 p.m. –Scott Guelcher, Ph.D. – Vanderbilt University
Remodeling of Nanocomposite Bone Grafts with Bone-like Strength in a Load-bearing Ovine Tibial Plateau Defect Model

3:00 p.m. – Break

SESSION VIII
Session Chair - Johnna Temenoff, Ph.D. - Georgia Tech / Emory University

3:30 p.m. – Keynote – David Gamm, M.D., Ph.D. – University of Wisconsin School of Medicine and Public Health
Production and Utilization of Human Pluripotent Stem Cell-derived Photoreceptors for the Treatment of Retinal Degenerative Diseases

4:00 p.m. – Eric Schmuck, Ph.D. – University of Wisconsin-Madison
Transfer of Mesenchymal Stem Cells with Cardiac Fibroblast Derived Extracellular Matrix Bioscaffold Improves Right Ventricular Function in a Rat Pulmonary Arterial Hypertension Model

4:20 p.m. – Todd Sulchek, Ph.D. – Georgia Tech 
Biophysical Markers of Stemness and their Uses for Cell Sorting

4:40 p.m. – Edmund Waller, M.D., Ph.D. – Emory University
Another Arrow in the Anti-cancer Quiver: VIP Immunotherapy

5:00 – 5:15 p.m. – Reception before Debate

5:15 – 6:40 p.m. – Debate – MSCs are not Stem Cells

Moderator
Bob Nerem, Ph.D. – Georgia Tech

Debaters
Arnold Caplan, Ph.D. – Case Western
Christopher Evans, Ph.D. – Mayo Clinic

7:10 p.m. – Conference Dinner – Sea Pines Beach Club – 87 N. Sea Pines Drive, Hilton Head Island, SC 29928 - transportation provided


Day 4 – Saturday, March 4, 2017

7:30 a.m. – Continental breakfast

SESSION IX
Session Chair - Bill Murphy, Ph.D. - University of Wisconsin-Madison

8:00 a.m. – Keynote – ACell Young Investigator Award Winner – Faculty – Swathi Balaji, Ph.D. - Baylor University  
Effect of Stretch on Extracellular Matrix and Morphology of Fibroblasts in Regenerative Wound Healing

8:30 a.m. – Natasha Case, Ph.D. – St. Louis University
A Macromolecular Crowding Approach Enhances Matrix Accumulation by Chondrogenic Cells

8:50 a.m. – Bryan Brown, Ph.D. – University of Pittsburgh
An Extracellular Matrix-based Device for Temporomandibular Joint Reconstruction

9:10 a.m. – Lohitash Karumbaiah, Ph.D. – University of Georgia
Oversulfated Chondroitin Sulfate Glycosaminoglycans in the Brain Tumor Microenvironment Promote Glioma Cell Invasion

9:30 a.m. – Young Investigator Award Winner – Postdoc – Jessica Weaver, Ph.D. – Georgia Tech
Vasculogenic Degradable Hydrogel to Enhance Islet Engraftment, Function, and Survival within Extrahepatic Transplant Sites

9:50 a.m. – Break

SESSION X
Session Chair - Steve Stice, Ph.D. - University of Georgia

10:10 a.m. – Scott Hollister, Ph.D. – Georgia Tech / Emory University
3D Patient Specific Airway Reconstruction: From Devices Towards Scaffolds

10:30 a.m. – Keat Ong, Ph.D. – Michigan Technological University
Wireless Implantable Sensors for Regenerative Medicine 

10:50 a.m. – Sean Murphy, Ph.D. – Wake Forest University
Amnion Membrane-derived Materials Accelerate Skin Wound Healing

11:10 a.m. – Aleksander Skardal, Ph.D. – Wake Forest University
Biofabrication of Tissue Constructs for Drug Screening, Disease Models, and Personalized Medicine

11:30 a.m. – Keynote – Clive Svendsen, Ph.D. – Cedars-Sinai
Organ-on-chip Systems to Model Human Disease

12:00 p.m.     CONFERENCE ADJOURNS